IL2RA

Gene

interleukin 2 receptor subunit alpha

HGNCHGNC:6008 EnsemblENSG00000134460 NCBI Gene3559

Locus: gene with protein productLocation: 10p15.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Interleukin-2 receptor subunit alphaP01589

Protein · therapeutic target

Clinically validated target · 4 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asIL2R · IDDM10 · CD25

View full nomenclature history (5)

Previous symbolsIL2R, IDDM10

Alias symbolsCD25

Previous namesinsulin-dependent diabetes mellitus 10, interleukin 2 receptor, alpha

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Sclerosis

Diabetes Mellitus, Type 1

Lymphoma, T-Cell, Cutaneous

Kidney transplant

Arthritis, Rheumatoid

Carcinoma, Renal Cell

Neoplasms

Hypothyroidism

Metastatic melanoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesInterleukin receptorsSushi domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.