IL2RB

Gene

interleukin 2 receptor subunit beta

HGNCHGNC:6009 EnsemblENSG00000100385 NCBI Gene3560

Locus: gene with protein productLocation: 22q12.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Interleukin-2 receptor subunit betaP14784

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asIL15RB · CD122

View full nomenclature history (4)

Previous symbolsIL15RB

Alias symbolsCD122

Previous namesinterleukin 15 receptor, beta, interleukin 2 receptor, beta

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Lymphoma, T-Cell, Cutaneous

Multiple Sclerosis

Carcinoma, Renal Cell

Neoplasms

Neurodegenerative Diseases

Metastatic melanoma

Immune System Diseases

Asthma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesInterleukin receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.