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ISCA2

Gene

iron-sulfur cluster assembly 2

HGNCHGNC:19857EnsemblENSG00000165898NCBI Gene122961
Locus: gene with protein productLocation: 14q24.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHBLD1 · ISA2
View full nomenclature history (4)
Previous symbolsHBLD1
Alias symbolsISA2
Previous namesHesB like domain containing 1, iron-sulfur cluster assembly 2 homolog (S. cerevisiae)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Optic Atrophy
Neurodegenerative Diseases
Genetic Diseases, Inborn
Optic Atrophy, Hereditary, Leber
Mitochondrial Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mitochondrial iron-sulfur assembly components

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.