ITCH

Gene

itchy E3 ubiquitin protein ligase

HGNCHGNC:13890 EnsemblENSG00000078747 NCBI Gene83737

Locus: gene with protein productLocation: 20q11.22

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAIP4

View full nomenclature history (3)

Alias symbolsAIP4

Previous namesitchy (mouse homolog) E3 ubiquitin protein ligase, itchy E3 ubiquitin protein ligase homolog (mouse)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Severe Acute Respiratory Syndrome

Non-alcoholic Fatty Liver Disease

Neurodegenerative Diseases

Genetic Diseases, Inborn

Metabolic Syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

C2 domain containingMicroRNA protein coding host genesNedd4 family E3 ubiquitin protein ligases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.