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ITGA2B

Gene

integrin subunit alpha 2b

HGNCHGNC:6138EnsemblENSG00000005961NCBI Gene3674
Locus: gene with protein productLocation: 17q21.31

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Integrin alpha-IIbP08514

Protein · therapeutic target

Clinically validated target · 4 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGP2B · CD41B · CD41 · PPP1R93 · GPIIb
View full nomenclature history (10)
Previous symbolsGP2B
Alias symbolsCD41B, CD41, PPP1R93, GPIIb
Previous namesintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B), integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Alias namesprotein phosphatase 1, regulatory subunit 93, platelet glycoprotein IIb of IIb/IIIa complex, Integrin alpha-IIb

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Autosomal dominant macrothrombocytopenia
Neoplasms
Myocardial Infarction
Acute Coronary Syndrome
Noonan syndrome
Cardiomyopathy, Hypertrophic
Costello syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesProtein phosphatase 1 regulatory subunitsIntegrin alpha subunitsHuman platelet antigens

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.