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KCND3

Gene

potassium voltage-gated channel subfamily D member 3

HGNCHGNC:6239EnsemblENSG00000171385NCBI Gene3752
Locus: gene with protein productLocation: 1p13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

A-type voltage-gated potassium channel KCND3Q9UK17

Protein · therapeutic target

Clinically validated target · 7 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSCA22 · SCA19 · Kv4.3 · KSHIVB
View full nomenclature history (7)
Previous symbolsSCA22, SCA19
Alias symbolsKv4.3, KSHIVB
Previous namesspinocerebellar ataxia 22, spinocerebellar ataxia 19, potassium voltage-gated channel, Shal-related subfamily, member 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Atrial Fibrillation
Myasthenia Gravis
Multiple Sclerosis
Lambert-Eaton Myasthenic Syndrome
Arrhythmias, Cardiac
Neurodegenerative Diseases
Congenital myasthenic syndromes

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Potassium voltage-gated channelsBTB domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.