KCNJ11

Gene

potassium inwardly rectifying channel subfamily J member 11

HGNCHGNC:6257 EnsemblENSG00000187486 NCBI Gene3767

Locus: gene with protein productLocation: 11p15.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

ATP-sensitive inward rectifier potassium channel 11Q14654

Protein · therapeutic target

Clinically validated target · 15 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKir6.2 · BIR

View full nomenclature history (5)

Alias symbolsKir6.2, BIR

Previous namespotassium inwardly-rectifying channel, subfamily J, member 11

Alias namesATP-sensitive inward rectifier potassium channel 11, beta-cell inward rectifier

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetes Mellitus, Type 2

Hyperinsulinemic hypoglycemia, familial, 2

Diabetes mellitus, permanent neonatal 2

Diabetes mellitus, transient neonatal, 3

Diabetes Mellitus

Permanent neonatal diabetes mellitus

Transient neonatal diabetes mellitus

MODY

autosomal dominant hyperinsulinism due to Kir6.2 deficiency

diazoxide-resistant focal hyperinsulinism due to Kir6.2 deficiency

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Potassium inwardly rectifying channel subfamily J

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.