KCNK18

Gene

potassium two pore domain channel subfamily K member 18

HGNCHGNC:19439 EnsemblENSG00000186795 NCBI Gene338567

Locus: gene with protein productLocation: 10q25.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Potassium channel subfamily K member 18Q7Z418

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTRESK-2 · K2p18.1 · TRESK2 · TRESK · TRIK

View full nomenclature history (8)

Alias symbolsTRESK-2, K2p18.1, TRESK2, TRESK, TRIK

Previous namespotassium channel, subfamily K, member 18, potassium channel, two pore domain subfamily K, member 18

Alias namesTWIK related spinal cord K+ channel

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Migraine Disorders

Neurodevelopmental Disorders

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Potassium two pore domain channel subfamily K

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.