KCNK2

Gene

potassium two pore domain channel subfamily K member 2

HGNCHGNC:6277 EnsemblENSG00000082482 NCBI Gene3776

Locus: gene with protein productLocation: 1q41

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Potassium channel subfamily K member 2O95069

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asK2p2.1 · TREK-1

View full nomenclature history (4)

Alias symbolsK2p2.1, TREK-1

Previous namespotassium channel, subfamily K, member 2, potassium channel, two pore domain subfamily K, member 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Arthritis, Psoriatic

Respiratory Distress Syndrome

Hypertension

Male reproductive organ cancer

Female reproductive system disorder

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Potassium two pore domain channel subfamily K

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.