KDM5B

Gene

lysine demethylase 5B

HGNCHGNC:18039 EnsemblENSG00000117139 NCBI Gene10765

Locus: gene with protein productLocation: 1q32.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asJARID1B · RBBP2H1A · PLU-1 · CT31 · PPP1R98

View full nomenclature history (10)

Previous symbolsJARID1B

Alias symbolsRBBP2H1A, PLU-1, CT31, PPP1R98

Previous namesJumonji, AT rich interactive domain 1B (RBP2-like), jumonji, AT rich interactive domain 1B, lysine (K)-specific demethylase 5B

Alias namescancer/testis antigen 31, protein phosphatase 1, regulatory subunit 98

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodevelopmental Disorders

Genetic Diseases, Inborn

Neurodegenerative Diseases

Autosomal recessive non-syndromic intellectual disability

Autism Spectrum Disorder

Psoriasis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

PHD finger proteinsAT-rich interaction domain containingLysine demethylases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.