KDM5D

Gene

lysine demethylase 5D

HGNCHGNC:11115 EnsemblENSG00000012817 NCBI Gene8284

Locus: gene with protein productLocation: Yq11.223

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHYA · HY · SMCY · JARID1D · KIAA0234

View full nomenclature history (9)

Previous symbolsHYA, HY, SMCY, JARID1D

Alias symbolsKIAA0234

Previous namesJumonji, AT rich interactive domain 1D (RBP2-like), Smcy homolog, Y-linked (mouse), jumonji, AT rich interactive domain 1D, lysine (K)-specific demethylase 5D

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms

Squamous Cell Carcinoma of Head and Neck

Amyotrophic Lateral Sclerosis

Ataxia Telangiectasia

Multiple Sclerosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

PHD finger proteinsAT-rich interaction domain containingLysine demethylasesMinor histocompatibility antigens

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.