KIT

Gene

KIT proto-oncogene, receptor tyrosine kinase

HGNCHGNC:6342 EnsemblENSG00000157404 NCBI Gene3815

Locus: gene with protein productLocation: 4q12

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Mast/stem cell growth factor receptor KitP10721

Protein · therapeutic target

Clinically validated target · 20 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPBT · CD117 · SCFR · C-Kit

View full nomenclature history (7)

Previous symbolsPBT

Alias symbolsCD117, SCFR, C-Kit

Previous namespiebald trait, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Alias namesmast/stem cell growth factor receptor Kit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Gastrointestinal Stromal Tumors

Piebaldism

Cutaneous mastocytosis

Leukemia, Myeloid, Acute

chronic myelogenous leukemia, BCR-ABL1 positive

Carcinoma, Hepatocellular

Mastocytosis

Neoplasms

Systemic mastocytosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesImmunoglobulin like domain containingCSF1R, KIT, FLT3 receptor tyrosine kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.