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L1CAM

Gene

L1 cell adhesion molecule

HGNCHGNC:6470EnsemblENSG00000198910NCBI Gene3897
Locus: gene with protein productLocation: Xq28

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Neural cell adhesion molecule L1P32004

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHSAS1 · SPG1 · HSAS · MASA · MIC5 · S10 · CD171 · NCAM-L1 · CAML1
View full nomenclature history (11)
Previous symbolsHSAS1, SPG1, HSAS, MASA, MIC5, S10
Alias symbolsCD171, NCAM-L1, CAML1
Previous namesantigen identified by monoclonal antibody R1
Alias namesneural cell adhesion molecule L1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesFibronectin type III domain containingI-set domain containingIg-like cell adhesion molecule family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.