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LIG4

Gene

DNA ligase 4

HGNCHGNC:6601EnsemblENSG00000174405NCBI Gene3981
Locus: gene with protein productLocation: 13q33.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

View full nomenclature history (7)
Previous namesligase IV, DNA, ATP-dependent
Alias namespolydeoxyribonucleotide synthase [ATP] 4, polynucleotide ligase, sealase, DNA repair enzyme, DNA joinase, DNA ligase IV

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Severe Combined Immunodeficiency
T-B- severe combined immunodeficiency
Genetic Diseases, Inborn
Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Multiple Myeloma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

DNA ligases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.