MAP2K1

Gene

mitogen-activated protein kinase kinase 1

HGNCHGNC:6840 EnsemblENSG00000169032 NCBI Gene5604

Locus: gene with protein productLocation: 15q22.31

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Dual specificity mitogen-activated protein kinase kinase 1Q02750

Protein · therapeutic target

Clinically validated target · 8 approved medicines against this target

Member of “Mitogen-Activated Protein Kinase Kinases” · 11 related family papers (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPRKMK1 · MEK1 · MAPKK1 · MKK1

View full nomenclature history (7)

Previous symbolsPRKMK1

Alias symbolsMEK1, MAPKK1, MKK1

Alias namesdual specificity mitogen-activated protein kinase kinase 1, MAPK/ERK kinase 1, MAP kinase kinase 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Cardiofaciocutaneous syndrome

Cardiofaciocutaneous syndrome 3

Noonan syndrome with multiple lentigines

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mitogen-activated protein kinase kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-08-02.

Open TargetsGene–disease associations from the Open Targets Platform.