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MAP2K3

Gene

mitogen-activated protein kinase kinase 3

HGNCHGNC:6843EnsemblENSG00000034152NCBI Gene5606
Locus: gene with protein productLocation: 17p11.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPRKMK3 · MEK3 · MKK3 · MAPKK3 · SAPKK2
View full nomenclature history (9)
Previous symbolsPRKMK3
Alias symbolsMEK3, MKK3, MAPKK3, SAPKK2
Alias namesMAPK/ERK kinase 3, MAP kinase kinase 3, dual specificity mitogen activated protein kinase kinase 3, stress-activated protein kinase kinase 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Autoimmune disorder of central nervous system
Hypothyroidism
Spontaneous coronary artery dissection

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mitogen-activated protein kinase kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-03-12.
Open TargetsGene–disease associations from the Open Targets Platform.