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MAP3K12

Gene

mitogen-activated protein kinase kinase kinase 12

HGNCHGNC:6851EnsemblENSG00000139625NCBI Gene7786
Locus: gene with protein productLocation: 12q13.13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asZPK · MUK · DLK · ZPKP1 · MEKK12
View full nomenclature history (6)
Previous symbolsZPK
Alias symbolsMUK, DLK, ZPKP1, MEKK12
Alias namesdual leucine zipper kinase DLK

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Parkinson's Disease
Genetic central nervous system malformation
Genetic developmental and epileptic encephalopathy
Autosomal recessive primary microcephaly

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mitogen-activated protein kinase kinase kinasesMixed lineage kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.