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MAPK1

Gene

mitogen-activated protein kinase 1

HGNCHGNC:6871EnsemblENSG00000100030NCBI Gene5594
Locus: gene with protein productLocation: 22q11.22

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPRKM2 · PRKM1 · ERK · ERK2 · p41mapk · MAPK2
View full nomenclature history (7)
Previous symbolsPRKM2, PRKM1
Alias symbolsERK, ERK2, p41mapk, MAPK2
Alias namesExtracellular signal-regulated kinase 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Noonan syndrome
Neoplasms
Cardiomyopathy, Hypertrophic
Costello syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mitogen-activated protein kinase 3 and 1 (ERK1/2) family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-08-02.
Open TargetsGene–disease associations from the Open Targets Platform.