MDM4

Gene

MDM4 regulator of p53

HGNCHGNC:6974 EnsemblENSG00000198625 NCBI Gene4194

Locus: gene with protein productLocation: 1q32.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMDMX · HDMX

View full nomenclature history (6)

Alias symbolsMDMX, HDMX

Previous namesmouse double minute 4, human homolog of; p53-binding protein, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse), Mdm4 p53 binding protein homolog (mouse), MDM4, p53 regulator

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Prostate carcinoma

Neurodegenerative Diseases

Triple Negative Breast Neoplasms

Prostatic Neoplasms

Actinic keratosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ring finger proteinsZinc fingers RANBP2-type

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.