MECP2

Gene

methyl-CpG binding protein 2

HGNCHGNC:6990 EnsemblENSG00000169057 NCBI Gene4204

Locus: gene with protein productLocation: Xq28

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Methyl-CpG-binding protein 2P51608

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRTT · MRX16 · MRX79

View full nomenclature history (8)

Previous symbolsRTT, MRX16, MRX79

Previous namesmethyl CpG binding protein 2 (Rett syndrome), mental retardation, X-linked 16, mental retardation, X-linked 79, Rett syndrome, methyl CpG binding protein 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Rett Syndrome

atypical Rett syndrome

Angelman Syndrome

Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Methyl-CpG binding domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.