MERTK

Gene

MER proto-oncogene, tyrosine kinase

HGNCHGNC:7027 EnsemblENSG00000153208 NCBI Gene10461

Locus: gene with protein productLocation: 2q13

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tyrosine-protein kinase MerQ12866

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asmer · RP38 · c-Eyk · Tyro12

View full nomenclature history (5)

Alias symbolsmer, RP38, c-Eyk, Tyro12

Previous namesc-mer proto-oncogene tyrosine kinase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Retinitis Pigmentosa

Dengue

Genetic Diseases, Inborn

Leber Congenital Amaurosis

Retinal Diseases

Eye Diseases

Atrial Fibrillation

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Fibronectin type III domain containingI-set domain containingAXL receptor tyrosine kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.