MRE11

Gene

MRE11 double strand break repair nuclease

HGNCHGNC:7230 EnsemblENSG00000020922 NCBI Gene4361

Locus: gene with protein productLocation: 11q21

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMRE11A · ATLD

View full nomenclature history (6)

Previous symbolsMRE11A

Alias symbolsATLD

Previous namesMRE11 homolog, double strand break repair nuclease, MRE11 meiotic recombination 11 homolog A (S. cerevisiae), MRE11 homolog A, double strand break repair nuclease

Alias namesAT-like disease

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplastic Syndromes, Hereditary

Inherited cancer-predisposing syndrome

Neoplasms

Colonic Neoplasms

Triple Negative Breast Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

BRCA1 C complexMRN complexMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-07-02.

Open TargetsGene–disease associations from the Open Targets Platform.