Back to discover

MSX2

Gene

msh homeobox 2

HGNCHGNC:7392EnsemblENSG00000120149NCBI Gene4488
Locus: gene with protein productLocation: 5q35.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPFM1 · CRS2 · FPP · HOX8 · MSH · PFM
View full nomenclature history (10)
Previous symbolsPFM1
Alias symbolsCRS2, FPP, HOX8, MSH, PFM
Previous namesmsh homeobox homolog 2 (Drosophila), msh (Drosophila) homeo box homolog 2, parietal foramina 1
Alias namescraniosynostosis, type 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hair color
Craniosynostoses
Atrial Fibrillation
Urinary Bladder Neoplasms
Pre-Eclampsia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NKL subclass homeoboxes and pseudogenes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.