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MT-ND4

Gene

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4

HGNCHGNC:7459EnsemblENSG00000198886NCBI Gene4538
Locus: gene with protein productLocation: mitochondria

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMTND4 · LHON · ND4 · NAD4
View full nomenclature history (9)
Previous symbolsMTND4, LHON
Alias symbolsND4, NAD4
Previous namesNADH dehydrogenase 4, Leber optic neuropathy, mitochondrially encoded NADH dehydrogenase 4
Alias namescomplex I ND4 subunit, NADH-ubiquinone oxidoreductase chain 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Optic Atrophy, Hereditary, Leber
Diabetes Mellitus, Type 2
Diabetes Mellitus

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NADH:ubiquinone oxidoreductase core subunitsMitochondrially encoded protein coding genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2021-12-02.
Open TargetsGene–disease associations from the Open Targets Platform.