MYL3

Gene

myosin light chain 3

HGNCHGNC:7584 EnsemblENSG00000160808 NCBI Gene4634

Locus: gene with protein productLocation: 3p21.31

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Myosin light chain 3P08590

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCMH8 · VLC1 · MLC1V · MLC1SB

View full nomenclature history (6)

Alias symbolsCMH8, VLC1, MLC1V, MLC1SB

Previous namesmyosin, light polypeptide 3, alkali; ventricular, skeletal, slow, myosin, light chain 3, alkali; ventricular, skeletal, slow

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Cardiomyopathy, Hypertrophic

Rare familial disorder with hypertrophic cardiomyopathy

Familial hypertrophic cardiomyopathy

Cardiovascular Diseases

Cardiomyopathies

Heart Failure

chondrodysplasia Blomstrand type

metaphyseal chondrodysplasia, Jansen type

Eiken syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Myosin light chains, class 1

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.