NBR1

Gene

NBR1 autophagy cargo receptor

HGNCHGNC:6746 EnsemblENSG00000188554 NCBI Gene4077

Locus: gene with protein productLocation: 17q21.31

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asM17S2 · CA125 · KIAA0049 · 1A1-3B

View full nomenclature history (6)

Previous symbolsM17S2

Alias symbolsCA125, KIAA0049, 1A1-3B

Previous namesneighbor of BRCA1 gene 1, membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Alzheimer's Disease

Hypocalcemic vitamin D-resistant rickets

bone Paget's disease

Neoplasms

Osteogenesis Imperfecta

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers ZZ-type

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.