NECTIN4

Gene

nectin cell adhesion molecule 4

HGNCHGNC:19688 EnsemblENSG00000143217 NCBI Gene81607

Locus: gene with protein productLocation: 1q23.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Nectin-4Q96NY8

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPVRL4 · nectin-4 · PRR4 · LNIR

View full nomenclature history (5)

Previous symbolsPVRL4

Alias symbolsnectin-4, PRR4, LNIR

Previous namespoliovirus receptor-related 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Ectodermal dysplasia - syndactyly syndrome

Urothelial carcinoma

Neoplasms

Urinary bladder carcinoma

Ectodermal dysplasia-syndactyly syndrome

Urogenital Neoplasms

Urinary Bladder Neoplasms

Amelogenesis imperfecta

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

V-set domain containingC2-set domain containingNectins and nectin-like molecules

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.