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NFAT5

Gene

nuclear factor of activated T cells 5

HGNCHGNC:7774EnsemblENSG00000102908NCBI Gene10725
Locus: gene with protein productLocation: 16q22.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA0827 · NFATL1 · OREBP · NFATZ · NF-AT5 · TONEBP
View full nomenclature history (9)
Alias symbolsKIAA0827, NFATL1, OREBP, NFATZ, NF-AT5, TONEBP
Previous namesnuclear factor of activated T-cells 5, nuclear factor of activated T-cells 5, tonicity-responsive
Alias namestonicity-responsive enhancer binding protein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetes Mellitus, Type 2
Diabetes Mellitus
Hyperuricemia
Helicobacter Infections
Kidney Failure, Chronic
Smoking initiation
Gout
Hypothyroidism
Coronary Artery Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Nuclear factors of activated T-cellsIPT domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.