NFKB1

Gene

nuclear factor kappa B subunit 1

HGNCHGNC:7794 EnsemblENSG00000109320 NCBI Gene4790

Locus: gene with protein productLocation: 4q24

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKBF1 · p105 · NFKB-p50 · p50 · NF-kappaB · NFkappaB · NF-kB1

View full nomenclature history (9)

Alias symbolsKBF1, p105, NFKB-p50, p50, NF-kappaB, NFkappaB, NF-kB1

Previous namesnuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Alias namesNuclear factor NF-kappa-B p105 subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Common variable immunodeficiency

Primary biliary cholangitis

Rhinitis, Allergic

Graves' Disease

Scleroderma, Systemic

Colitis, Ulcerative

Hypothyroidism

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ankyrin repeat domain containingNF-kappa B complex subunitsIPT domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.