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NFKB2

Gene

nuclear factor kappa B subunit 2

HGNCHGNC:7795EnsemblENSG00000077150NCBI Gene4791
Locus: gene with protein productLocation: 10q24.32

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asLYT-10 · p52 · p105 · NF-kB2 · p49/p100
View full nomenclature history (6)
Alias symbolsLYT-10, p52, p105, NF-kB2, p49/p100
Previous namesnuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Common variable immunodeficiency
Hodgkin's Disease
Alzheimer's Disease
Parkinson's Disease
Immunologic Deficiency Syndromes
Colonic Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ankyrin repeat domain containingNF-kappa B complex subunitsIPT domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.