Back to discover

NLRP1

Gene

NLR family pyrin domain containing 1

HGNCHGNC:14374EnsemblENSG00000091592NCBI Gene22861
Locus: gene with protein productLocation: 17p13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNALP1 · SLEV1 · KIAA0926 · DKFZp586O1822 · CARD7 · NAC · CLR17.1 · DEFCAP · VAMAS1
View full nomenclature history (12)
Previous symbolsNALP1, SLEV1
Alias symbolsKIAA0926, DKFZp586O1822, CARD7, NAC, CLR17.1, DEFCAP, VAMAS1
Previous namesNACHT, leucine rich repeat and PYD (pyrin domain) containing 1, systemic lupus erythematosus, vitiligo-related 1
Alias namesnucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Vitiligo
Eye Diseases
Migraine Disorders
Gastrointestinal Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NLR familyCaspase recruitment domain containingPyrin domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.