NPC1L1

Gene

NPC1 like intracellular cholesterol transporter 1

HGNCHGNC:7898 EnsemblENSG00000015520 NCBI Gene29881

Locus: gene with protein productLocation: 7p13

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

NPC1-like intracellular cholesterol transporter 1Q9UHC9

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSLC65A2

View full nomenclature history (4)

Alias symbolsSLC65A2

Previous namesNPC1 (Niemann-Pick disease, type C1, gene)-like 1, NPC1-like 1, NPC1 like 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hyperlipidemias

Familial hypercholesterolemia

Inherited lipid metabolism disorder

Cardiovascular Diseases

Atherosclerosis

Metabolic Diseases

Coronary Artery Disease

Diabetes Mellitus, Type 2

Diabetes Mellitus

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Solute carrier family 65

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-14.

Open TargetsGene–disease associations from the Open Targets Platform.