Back to discover

NPR2

Gene

natriuretic peptide receptor 2

HGNCHGNC:7944EnsemblENSG00000159899NCBI Gene4882
Locus: gene with protein productLocation: 9p13.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Atrial natriuretic peptide receptor 2P20594

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asANPRB · NPRB · AMDM · GUCY2B · ANPb · GC-B
View full nomenclature history (11)
Previous symbolsANPRB, NPRB, AMDM
Alias symbolsGUCY2B, ANPb, GC-B
Previous namesacromesomelic dysplasia, Maroteaux type, atrionatriuretic peptide receptor B, natriuretic peptide receptor B
Alias namesguanylate cyclase 2B, guanylyl cyclase B

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Achondroplasia
Heart Failure
Familial focal epilepsy with variable foci
Genetic Diseases, Inborn
Bone Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Transmembrane guanylate cyclasesDENN domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.