NR1D1

Gene

nuclear receptor subfamily 1 group D member 1

HGNCHGNC:7962 EnsemblENSG00000126368 NCBI Gene9572

Locus: gene with protein productLocation: 17q21.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Nuclear receptor subfamily 1 group D member 1P20393

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTHRAL · ear-1 · hRev · Rev-ErbAalpha · THRA1 · REVERBA · REVERBalpha

View full nomenclature history (8)

Previous symbolsTHRAL

Alias symbolsear-1, hRev, Rev-ErbAalpha, THRA1, REVERBA, REVERBalpha

Previous namesnuclear receptor subfamily 1, group D, member 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Peripheral resistance to thyroid hormones

Neurodegenerative Diseases

Asthma

Peptic ulcer disease

Genetic Diseases, Inborn

Neoplasms

Stomach Neoplasms

Breast Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Nuclear receptor subfamily 1 group D

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.