NR3C1

Gene

nuclear receptor subfamily 3 group C member 1

HGNCHGNC:7978 EnsemblENSG00000113580 NCBI Gene2908

Locus: gene with protein productLocation: 5q31.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Glucocorticoid receptorP04150

Protein · therapeutic target

Clinically validated target · 55 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGRL · GR

View full nomenclature history (5)

Previous symbolsGRL

Alias symbolsGR

Previous namesglucocorticoid receptor, nuclear receptor subfamily 3, group C, member 1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Glucocorticoid resistance

Pulmonary Disease, Chronic Obstructive

Multiple Sclerosis

Arthritis, Rheumatoid

Purpura, Thrombocytopenic, Idiopathic

Osteoarthritis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Nuclear receptor subfamily 3 group C

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.