NR3C2

Gene

nuclear receptor subfamily 3 group C member 2

HGNCHGNC:7979 EnsemblENSG00000151623 NCBI Gene4306

Locus: gene with protein productLocation: 4q31.23

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Mineralocorticoid receptorP08235

Protein · therapeutic target

Clinically validated target · 13 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMLR · MR

View full nomenclature history (4)

Previous symbolsMLR

Alias symbolsMR

Previous namesmineralocorticoid receptor, nuclear receptor subfamily 3, group C, member 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Autosomal dominant pseudohypoaldosteronism type 1

Hypertension

Renal pseudohypoaldosteronism type 1

Pseudohyperaldosteronism type 2

Heart Failure

Myocardial Infarction

Kidney Failure, Chronic

Diabetes Mellitus, Type 2

Nephrotic Syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Nuclear receptor subfamily 3 group C

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-01-15.

Open TargetsGene–disease associations from the Open Targets Platform.