NSUN2

Gene

NOP2/Sun RNA methyltransferase 2

HGNCHGNC:25994 EnsemblENSG00000037474 NCBI Gene54888

Locus: gene with protein productLocation: 5p15.31

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMRT5 · FLJ20303 · TRM4 · Misu · SAKI

View full nomenclature history (11)

Previous symbolsMRT5

Alias symbolsFLJ20303, TRM4, Misu, SAKI

Previous namesNOL1/NOP2/Sun domain family, member 2, NOP2/Sun domain family, member 2, mental retardation, non-syndromic, autosomal recessive, 5

Alias namestRNA methyltransferase 4 homolog (S. cerevisiae), Myc-induced SUN-domain-containing protein, RNA cytosine C(5)-methyltransferase NSUN2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Autosomal recessive non-syndromic intellectual disability

Genetic Diseases, Inborn

Phenylketonurias

Neurodegenerative Diseases

Neoplasms

Cardiomyopathy, Hypertrophic

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NOP2/Sun RNA methyltransferase familyDNA/RNA methyltransferases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.