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OPA1

Gene

OPA1 mitochondrial dynamin like GTPase

HGNCHGNC:8140EnsemblENSG00000198836NCBI Gene4976
Locus: gene with protein productLocation: 3q29

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNTG · KIAA0567 · FLJ12460 · NPG · MGM1
View full nomenclature history (10)
Alias symbolsNTG, KIAA0567, FLJ12460, NPG, MGM1
Previous namesoptic atrophy 1 (autosomal dominant), OPA1, mitochondrial dynamin like GTPase
Alias namesmitochondrial dynamin-like GTPase, dynamin-like guanosine triphosphatase, Dynamin-like 120 kDa protein, mitochondrial

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Optic Atrophy
Neurodegenerative Diseases
Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Dynamin superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.