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OPA3

Gene

outer mitochondrial membrane lipid metabolism regulator OPA3

HGNCHGNC:8142EnsemblENSG00000125741NCBI Gene80207
Locus: gene with protein productLocation: 19q13.32

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFLJ22187 · MGA3
View full nomenclature history (5)
Alias symbolsFLJ22187, MGA3
Previous namesoptic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia), OPA3, outer mitochondrial membrane lipid metabolism regulator
Alias names3-methylglutaconic aciduria type III

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Color Vision Defects
Genetic Diseases, Inborn
Alzheimer's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.