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ORAI1

Gene

ORAI calcium release-activated calcium modulator 1

HGNCHGNC:25896EnsemblENSG00000276045NCBI Gene84876
Locus: gene with protein productLocation: 12q24.31

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Calcium release-activated calcium channel protein 1Q96D31

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTMEM142A · FLJ14466 · CRACM1
View full nomenclature history (5)
Previous symbolsTMEM142A
Alias symbolsFLJ14466, CRACM1
Previous namestransmembrane protein 142A
Alias namescalcium release-activated calcium modulator 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Severe Combined Immunodeficiency
T-B- severe combined immunodeficiency

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

ORAI calcium release-activated calcium modulators

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2021-05-26.
Open TargetsGene–disease associations from the Open Targets Platform.