P4HB

Gene

prolyl 4-hydroxylase subunit beta

HGNCHGNC:8548 EnsemblENSG00000185624 NCBI Gene5034

Locus: gene with protein productLocation: 17q25.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPO4DB · ERBA2L · PDIA1 · PROHB · DSI · GIT · PDI · PO4HB · P4Hbeta

View full nomenclature history (16)

Previous symbolsPO4DB, ERBA2L

Alias symbolsPDIA1, PROHB, DSI, GIT, PDI, PO4HB, P4Hbeta

Previous namesprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1), procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide, prolyl 4-hydroxylase, beta polypeptide, procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55)

Alias namesprotein disulfide isomerase-associated 1, protein disulfide isomerase family A, member 1, collagen prolyl 4-hydroxylase beta

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Familial hypercholesterolemia

Dengue

Cardiovascular Diseases

Genetic Diseases, Inborn

Osteogenesis Imperfecta

Breast Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Protein disulfide isomerasesProlyl 4-hydroxylase subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.