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PARN

Gene

poly(A)-specific ribonuclease

HGNCHGNC:8609EnsemblENSG00000140694NCBI Gene5073
Locus: gene with protein productLocation: 16p13.12

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDAN
View full nomenclature history (3)
Alias symbolsDAN
Previous namespoly(A)-specific ribonuclease (deadenylation nuclease)
Alias namesdeadenylation nuclease

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Idiopathic Pulmonary Fibrosis
Dyskeratosis congenita
Pulmonary Fibrosis
Lung Diseases, Interstitial
Metabolic Syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ribosome biogenesis factorsPARN exonuclease family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-05-17.
Open TargetsGene–disease associations from the Open Targets Platform.