PCSK1N

Gene

proprotein convertase subtilisin/kexin type 1 inhibitor

HGNCHGNC:17301 EnsemblENSG00000102109 NCBI Gene27344

Locus: gene with protein productLocation: Xp11.23

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSAAS · SgVIII · SCG8 · proSAAS · PEN · BigLEN

View full nomenclature history (6)

Alias symbolsSAAS, SgVIII, SCG8, proSAAS, PEN, BigLEN

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetes Mellitus, Type 2

Carcinoma, Renal Cell

Thyroid gland papillary carcinoma

Diabetes, Gestational

Liver Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Granins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.