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PCSK6

Gene

proprotein convertase subtilisin/kexin type 6

HGNCHGNC:8569EnsemblENSG00000140479NCBI Gene5046
Locus: gene with protein productLocation: 15q26.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPACE4 · SPC4
View full nomenclature history (6)
Previous symbolsPACE4
Alias symbolsSPC4
Previous namespaired basic amino acid cleaving system 4
Alias namessubtilisin-like protease, subtilisin-like proprotein convertase 4, subtilisin/kexin-like protease PACE4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Wet macular degeneration
Placental retention
Peripheral Arterial Disease
Central Nervous System Neoplasms
Angina Pectoris
Myocardial Ischemia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Proprotein convertase subtilisin/kexin family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.