PDGFRB

Gene

platelet derived growth factor receptor beta

HGNCHGNC:8804 EnsemblENSG00000113721 NCBI Gene5159

Locus: gene with protein productLocation: 5q32

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Platelet-derived growth factor receptor betaP09619

Protein · therapeutic target

Clinically validated target · 19 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPDGFR · JTK12 · CD140b · PDGFR1

View full nomenclature history (5)

Previous symbolsPDGFR

Alias symbolsJTK12, CD140b, PDGFR1

Previous namesplatelet-derived growth factor receptor, beta polypeptide

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Bilateral striopallidodentate calcinosis

Myofibromatosis, infantile, 1

Infantile myofibromatosis

Skeletal overgrowth-craniofacial dysmorphism-hyperelastic skin-white matter lesions syndrome

Acroosteolysis-keloid-like lesions-premature aging syndrome

Carcinoma, Hepatocellular

Gastrointestinal Stromal Tumors

chronic myelogenous leukemia, BCR-ABL1 positive

Leukemia, Myeloid, Acute

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesI-set domain containingPlatelet derived growth factor receptor family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.