PIK3R1

Gene

phosphoinositide-3-kinase regulatory subunit 1

HGNCHGNC:8979 EnsemblENSG00000145675 NCBI Gene5295

Locus: gene with protein productLocation: 5q13.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGRB1 · p85-ALPHA · p85 · p85alpha

View full nomenclature history (8)

Alias symbolsGRB1, p85-ALPHA, p85, p85alpha

Previous namesphosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Alias namesphosphoinositide-3-kinase regulatory subunit alpha, growth factor receptor bound 1, PI3 kinase-associated p85

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms

Autosomal agammaglobulinemia

Bone development disease

Endometrial Neoplasms

Isolated agammaglobulinemia

Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SH2 domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.