Back to discover

PLCG1

Gene

phospholipase C gamma 1

HGNCHGNC:9065EnsemblENSG00000124181NCBI Gene5335
Locus: gene with protein productLocation: 20q12

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPLC1 · PLC148 · PLC-II · PLCgamma1 · NCKAP3
View full nomenclature history (7)
Previous symbolsPLC1
Alias symbolsPLC148, PLC-II, PLCgamma1, NCKAP3
Previous namesphospholipase C, gamma 1 (formerly subtype 148), phospholipase C, gamma 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms
Bone development disease
Leishmaniasis, Cutaneous
Gastric carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

PhospholipasesPleckstrin homology domain containingSH2 domain containingC2 domain containing phospholipasesEF-hand domain containingMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.