PLEKHG5

Gene

pleckstrin homology and RhoGEF domain containing G5

HGNCHGNC:29105 EnsemblENSG00000171680 NCBI Gene57449

Locus: gene with protein productLocation: 1p36.31

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA0720 · Syx · GEF720 · Tech · ARHGEF45

View full nomenclature history (7)

Alias symbolsKIAA0720, Syx, GEF720, Tech, ARHGEF45

Previous namespleckstrin homology domain containing, family G (with RhoGef domain) member 5

Alias namessynectin-binding guanine exchange factor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn

Neuromuscular Diseases

Neurodegenerative Diseases

Charcot-Marie-Tooth Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containingDbl family Rho GEFs

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-06-08.

Open TargetsGene–disease associations from the Open Targets Platform.