PNPLA3

Gene

patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase

HGNCHGNC:18590 EnsemblENSG00000100344 NCBI Gene80339

Locus: gene with protein productLocation: 22q13.31

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC22orf20 · ADPN · dJ796I17.1 · FLJ22012 · iPLA2epsilon

View full nomenclature history (9)

Previous symbolsC22orf20, ADPN

Alias symbolsdJ796I17.1, FLJ22012, iPLA2epsilon

Previous namesadiponutrin, chromosome 22 open reading frame 20, patatin like phospholipase domain containing 3, patatin-like phospholipase domain containing 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Non-alcoholic Fatty Liver Disease

Liver Diseases

Gout

Liver Cirrhosis

Diabetes Mellitus, Type 2

Carcinoma, Hepatocellular

Diabetes Mellitus

Liver Diseases, Alcoholic

Esophageal and Gastric Varices

Liver Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

LipasesPatatin like phospholipase domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-02-13.

Open TargetsGene–disease associations from the Open Targets Platform.