Back to discover

POLD3

Gene

DNA polymerase delta 3, accessory subunit

HGNCHGNC:20932EnsemblENSG00000077514NCBI Gene10714
Locus: gene with protein productLocation: 11q13.4

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

DNA polymerase delta subunit 3Q15054

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asP66 · KIAA0039 · P68 · PPP1R128
View full nomenclature history (9)
Alias symbolsP66, KIAA0039, P68, PPP1R128
Previous namespolymerase (DNA-directed), delta 3, accessory subunit, polymerase (DNA) delta 3, accessory subunit
Alias namesDNA polymerase delta subunit p66, Pol delta C subunit (p66), protein phosphatase 1, regulatory subunit 128

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Myeloid, Acute
Ovarian carcinoma
Neoplasms
Myelodysplastic syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

DNA polymerasesProtein phosphatase 1 regulatory subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.